Stannous Chloride → 3-Bromo-2-fluoroaniline

Under argon, 1.0 g (4.54 mmol) of 3-bromo-2-fluoronitrobenzene was initially charged in 5 ml of dioxane, and 4.3 g (22.72 mmol) of tin(II) chloride and a few drops of 1 N hydrochloric acid were added. After 2 h of stirring, the reaction mixture was concentrated on a rotary evaporator and the residue was taken up in ethyl acetate. The organic phase was washed with 1 N aqueous sodium hydroxide solution, water and saturated sodium chloride solution and then dried over magnesium sulfate and concentrated. This gave 826 mg (95% of theory) of the title compound.

1. concentrationthe reaction mixture was concentrated on a rotary evaporator
2. washThe organic phase was washed with 1 N aqueous sodium hydroxide solution, water and saturated sodium chloride solution
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated

ORD record

ord-71bb758042b343c7b9b3b5a5d80e5a3d

Source dataset

uspto-grants-2015_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08987256B2