反应详情

温度

0 °C

740 mg (4.04 mmol) of 5,6-difluoro-1H-isoindole-1,3(2H)-dione were dissolved in 6.6 ml of ethanol, the mixture was cooled to 0° C. and 76.4 mg (2.02 mmol) of sodium borohydride were added a little at a time. After the addition had ended, the reaction mixture was slowly warmed to RT and stirred at RT for another 30 min before the reaction mixture was adjusted to neutral with 1 N hydrochloric acid. The mixture was concentrated to dryness under reduced pressure, and the residue was dried further under high vacuum. This gave 800.8 mg of crude product which was used without further purification for the next reaction.

1. additionAfter the addition
2. temperaturethe reaction mixture was slowly warmed to RT
3. concentrationThe mixture was concentrated to dryness under reduced pressure
4. customthe residue was dried further under high vacuum
5. customThis gave 800.8 mg of crude product which was used without further purification for the next reaction