反应详情

To a solution of methyl 4-(2-methoxyvinyl)benzoate (1.36 g, 7.08 mmol) in methanol (30 mL) was added para-toluenesulfonic acid monohydrate (pTSA) (0.135 g, 0.71 mmol) and the reaction mixture heated under reflux for 18 hours. The solvent was evaporated at reduced pressure. The residue was partitioned between DCM and 10% aqueous potassium carbonate. The organic phase was poured through a hydrophobic fit and the solvent evaporated at reduced pressure. The crude material was used in the next step without further purification.

1. temperaturethe reaction mixture heated
2. temperatureunder reflux for 18 hours
3. customThe solvent was evaporated at reduced pressure
4. customThe residue was partitioned between DCM and 10% aqueous potassium carbonate
5. additionThe organic phase was poured through a hydrophobic fit
6. customthe solvent evaporated at reduced pressure
7. customThe crude material was used in the next step without further purification