関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrogen Bromide | HCID 260 | — |
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | (3-Methoxyphenyl)(phenyl)methanone | HCID 12451863 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 3-Hydroxybenzophenone | HCID 83050 | 91% |
反応手順
1458 g (6.9 mol) of (3-methoxyphenyl)(phenyl)methanone was dissolved in 2090 mL of AcOH. To the solution, 2320 ml (20.6 mol) of 48% HBr was added and the mixture was stirred at 90° C. for 18 hours. The reaction was monitored by TLC (AcOEt:hex 1:9). After reaction was completed the mixture was cooled down to RT and poured into ice with stirring. The precipitated solid was filtered, washed with water and dried yielding the title compound as a white solid (1234 g, 91%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08987299B2 |
|---|
| 出典データセット | uspto-grants-2015_03 |
|---|
| ORD ID | ord-09b1192e5f4e462c8943dcb322ea8fd5 |
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| 出典メモ | uspto-grants-2015_03 |
|---|
