反应详情

To a 5 L three neck round bottom flask equipped with a mechanic stirrer, a pressure-equalizing funnel and a condenser bearing a calcium chloride drying tube was added glycine ethyl ester hydrochloride (500 g, 3.583 mol) and methyl formate (1.8 L). The suspension was brought to reflux and triethylamine (556 mL) was added to the reaction. The reaction was stirred and refluxed overnight. The reaction was cooled to room temperature and filtered through a Buchner funnel to remove triethylamine hydrochloride salt. The filtrate was concentrated and dried over high vacuum to yield 320 g (93%) of the title compound.

1. temperatureto reflux
2. temperaturerefluxed overnight
3. filtrationfiltered through a Buchner funnel
4. customto remove triethylamine hydrochloride salt
5. concentrationThe filtrate was concentrated
6. customdried over high vacuum