Ammonia → HCID 20162830, compound

A solution of diphenylamine (3.05 g, 18 mmol) and triethylamine (6 mL, 43 mmol) in THF (62 mL) was added dropwise to a stirred solution of triphosgene (1.99 g, 6.7 mmol) in THF (37 mL) at room temperature. The reaction mixture was heated to reflux overnight. Then, a solution of diphenylamine (3.1 g, 18 mmol) and triethylamine (5.8 mL, 42 mmol) in THF (37 mL) was added. The reaction mixture was stirred overnight at reflux temperature. The reaction mixture was filtered and the filtrate was evaporated to dryness, yielding tetraphenylurea as a yellow solid. Yield: 6.0 g (91%). Oxalyl chloride (1.8 mL, 21 mmol) was added to a stirred solution of the urea (6.0 g, 16 mmol) in diethyl ether (65 mL). The reaction mixture was evaporated to dryness after stirring for 2 days at reflux. A solution of ammonia in methanol (5 mL, 35 mmol, 7 M) was added. The reaction mixture was heated to reflux overnight and evaporated to dryness. The product was neutralized and purified from ammonium chloride by several treatments with aqueous sodium hydroxide solutions. The organic layer was extracted and dried over sodium sulfate. Crystallization from diethyl ether at low temperature yielded the desired guanidine as a white solid. Yield: 2.0 g (33%). 13C NMR (CDCl3, 75 MHz): δ 121.4, 126.7, 128.6, 140.3, 164.5 ppm.

1. customThe reaction mixture was evaporated to dryness
2. temperatureat reflux
3. temperatureThe reaction mixture was heated
4. temperatureto reflux overnight
5. customevaporated to dryness
6. custompurified from ammonium chloride by several treatments with aqueous sodium hydroxide solutions
7. extractionThe organic layer was extracted
8. dry with materialdried over sodium sulfate
9. customCrystallization from diethyl ether at low temperature

ORD record

ord-b261aca51a294b58b9ba0bc75b6d9cd2

Source dataset

uspto-grants-2015_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08987393B2