反应详情

温度

27.5 °C

Mixture of ethyl 2-((4R,6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (60 grams), tetra butyl ammonium bromide (79 grams) and anhydrous sodium acetate (61.2 grams) was heated to reflux temperature and stirred. After the completion of the reaction, the reaction mixture was cooled to 25-30° C. and petroleum ether (50 ml) was added to it then stirred for 60 minutes at 25-30° C. The reaction mixture was filtered and washed with petroleum ether. The solvent from the filtrate was distilled off under reduced pressure to get the title compound.

1. temperaturewas heated
2. temperatureto reflux temperature
3. customAfter the completion of the reaction
4. stirringthen stirred for 60 minutes at 25-30° C
5. filtrationThe reaction mixture was filtered
6. washwashed with petroleum ether
7. distillationThe solvent from the filtrate was distilled off under reduced pressure