反应详情

Mixture of n-butyl amine (100 grams), methyl 2-((4R,6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (20 grams) was heated to reflux and stirred. After completion of the reaction, distilled off n-butylamine under reduced pressure at below 60° C. The obtained residue was further purified using mixture of cyclohexane and ethyl acetate.

1. temperaturewas heated
2. temperatureto reflux
3. customAfter completion of the reaction
4. distillationdistilled off n-butylamine under reduced pressure at below 60° C
5. customThe obtained residue was further purified
6. additionmixture of cyclohexane and ethyl acetate