HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butylamine → N-butyl-2-((4R,6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butylamine | HCID 8007 | — |
| Reactant | methyl 2-((4R,6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate | HCID 10560752 | — |
| Product | N-butyl-2-((4R,6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetamide | HCID 53339170 | — |
Reaction Steps
Mixture of n-butyl amine (100 grams), methyl 2-((4R,6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (20 grams) was heated to reflux and stirred. After completion of the reaction, distilled off n-butylamine under reduced pressure at below 60° C. The obtained residue was further purified using mixture of cyclohexane and ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987444B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-c26ec31d65c3469187fb99e824e69962 |
| Source note | uspto-grants-2015_03 |