反应详情

温度

42.5 °C

A mixture of tert-butyl 2-((4R,6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (10 grams), methanol (80 ml), n-butyl amine (20 ml) and potassium carbonate (10.6 grams) was heated to 40-45° C. and stirred up to completion of the reaction. The reaction mixture was distilled under reduced pressure and methylene chloride (100 ml) was added to the obtained residue at 25-30° C. and stirred for 15 minutes. The unwanted solid was filtered off and the filtrate was distilled off under reduced pressure to get the title compound.

1. distillationThe reaction mixture was distilled under reduced pressure and methylene chloride (100 ml)
2. additionwas added to the obtained residue at 25-30° C.
3. stirringstirred for 15 minutes
4. filtrationThe unwanted solid was filtered off
5. distillationthe filtrate was distilled off under reduced pressure