HCID 70663581, compound → HCID 43114092, compound

HRID 877987Notes

Reaction equation

HRID 877987 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][C:9]=1[N+:14]([O-])=O.[H][H]>[Pd].CCO>[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][C:9]=1[NH2:14]

Participants

5

Reactant 2

HCID 70663581HCID 70663581, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 43114092HCID 43114092, compoundYield 36%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

2-Methyl-3′-nitro-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl (650 mg, 2.94 mmol) and 10% palladium on carbon (156 mg, 0.15 mmol) in EtOH were stirred under 1 atmosphere of hydrogen gas for 16 hours. Filtration followed by removal of volatiles under reduced pressure gave the title compound (200 mg, 36%) which was used in the next step without further purification.

Workup

  1. filtrationFiltration
  2. customfollowed by removal of volatiles under reduced pressure

Sources & evidence

ORD record
ord-9e43d6607acb4147aa4263c502ae9202
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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