HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Bis(trifluoromethyl)benzoyl chloride → N-(2'-Chloro-3'-fluoro-[4,4']bipyridinyl-3-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Bis(trifluoromethyl)benzoyl chloride | HCID 101856 | — |
| Reactant | (2'-Chloro-3'-fluoro-[4,4]bipyridinyl-3-yl)-methyl-amine | HCID 86670705 | — |
| Product | N-(2'-Chloro-3'-fluoro-[4,4']bipyridinyl-3-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide | HCID 60197498 | — |
Reaction Steps
The title compound was prepared in analogy to example 55, from (2′-chloro-3′-fluoro-[4,4]bipyridinyl-3-yl)-methyl-amine and 3,5-bis(trifluoromethyl)benzoyl chloride (CAS RN 1271-19-8) and using preparative HPLC for the chromatographic purification. Off-white solid (12%). MS (ESI): m/z=478.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-dd3230f19e0c450591edecbc62430df8 |
| Source note | uspto-grants-2015_03 |