2-Chloro-3-fluoro-4-iodopyridine → (2'-Chloro-3'-fluoro-[4,4]bipyridinyl-3-yl)-methyl-amine

HRID 878035Notes

Reaction equation

HRID 878035 reaction equation
[Cl:1][C:2]1[C:7]([F:8])=[C:6](I)[CH:5]=[CH:4][N:3]=1.[CH3:10][N:11]([C:28]1[CH:29]=[N:30][CH:31]=[CH:32][C:33]=1N1CCCCC1C)C(=O)C1C=C(C(F)(F)F)C=C(C(F)(F)F)C=1>>[Cl:1][C:2]1[C:7]([F:8])=[C:6]([C:33]2[CH:32]=[CH:31][N:30]=[CH:29][C:28]=2[NH:11][CH3:10])[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 110650872-Chloro-3-fluoro-4-iodopyridineHCID 86670691N-Methyl-N-(2-methyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-3'-yl)-3,5-bis-trifluoromethyl-benzamide2×

Product 1

HCID 86670705(2'-Chloro-3'-fluoro-[4,4]bipyridinyl-3-yl)-methyl-amine

Procedure

The title compound was prepared in analogy to example 55, intermediate, from 2-chloro-3-fluoro-4-iodo-pyridine (CAS RN 148639-07-0) and (4-iodo-pyridin-3-yl)-methyl-amine (example 36, intermediate b). Brown sticky solid (86%). MS (ESI): m/z=238.0 [M+H]+.

Sources & evidence

ORD record
ord-bc708d68db9740039717f753fd91180e
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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