N-Methyl-N-(2-methyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-3'-yl)-3,5-bis-trifluoromethyl-benzamide → Methyl-(3-methyl-[2,4]bipyridinyl-3'-yl)-amine

HRID 878037Notes

Reaction equation

HRID 878037 reaction equation
[Br-].[CH3:2][C:3]1[C:4]([Zn+])=[N:5][CH:6]=[CH:7][CH:8]=1.[CH3:10][N:11]([C:28]1[CH:29]=[N:30][CH:31]=[CH:32][C:33]=1N1CCCCC1C)C(=O)C1C=C(C(F)(F)F)C=C(C(F)(F)F)C=1>>[CH3:10][NH:11][C:28]1[CH:29]=[N:30][CH:31]=[CH:32][C:33]=1[C:4]1[C:3]([CH3:2])=[CH:8][CH:7]=[CH:6][N:5]=1

Participants

3

Reactant 2

HCID 86670691N-Methyl-N-(2-methyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-3'-yl)-3,5-bis-trifluoromethyl-benzamide2×HCID 178426320HCID 178426320, compound

Product 1

HCID 70663197Methyl-(3-methyl-[2,4]bipyridinyl-3'-yl)-amine

Procedure

The title compound was prepared in analogy to example 55, intermediate, from 3-methyl-2-pyridylzinc bromide (CAS RN 308795-91-7) and (4-iodo-pyridin-3-yl)-methyl-amine (example 36, intermediate b). Light yellow sticky solid (93%). MS (ESI): m/z=200.3 [M+H]+.

Sources & evidence

ORD record
ord-5394ea5d37634eaf91bf7df10ad7f688
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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