(3,4-Difluoro-2-methoxyphenyl)boronic acid → N-[4-(3,4-Difluoro-2-methoxy-phenyl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide

Participants

Role	Name	HCID	Charge
Reactant	(3,4-Difluoro-2-methoxyphenyl)boronic acid	HCID 53216751	—
Reactant	N-(4-bromo-pyridin-3-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide	HCID 86670692	—
Product	N-[4-(3,4-Difluoro-2-methoxy-phenyl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide	HCID 86670707	—

Reaction Steps

The title compound was prepared in analogy to example 58, from N-(4-bromo-pyridin-3-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide (example 25, intermediate a) and 2-methoxy-3,4-difluorophenylboronic acid (CAS RN 905583-06-4) and using preparative HPLC for the chromatographic purification. Off-white solid (49%). MS (ESI): m/z=491.1 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08987307B2
Source dataset	uspto-grants-2015_03
ORD ID	ord-46c88e0c06844e58a3a1381fc408a965
Source note	uspto-grants-2015_03