HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Methoxypyridine-2-boronic acid → HCID 60196806, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Methoxypyridine-2-boronic acid | HCID 2762741 | — |
| Reactant | N-(4-iodopyridin-3-yl)-N-methyl-3,5-bis(trifluoromethyl)benzamide | HCID 86670697 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | HCID 60196806 | HCID 60196806 | — |
Reaction Steps
The title compound was prepared in analogy to example 72, from N-(4-iodo-pyridin-3-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide and 6-methoxypyridin-2-ylboronic acid (CAS RN 372963-51-4) and using a gradient of n-heptane:EtOAc (100:0 to 60:40) for the chromatographic purification. The product was purified a second time by preparative HPLC (Phenomenex Gemini® column) eluting with a gradient of acetonitrile:water (50:50 to 95:5). Colorless oil (17%). MS (ESI): m/z=456.114 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-497132a31683418bbdf2111fb6b80e61 |
| Source note | uspto-grants-2015_03 |