2-Chlorophenylboronic acid → HCID 70663414, compound

HRID 878130Notes

Reaction equation

HRID 878130 reaction equation
[C:1]([O:5][C:6](=[O:18])[N:7]([C:11]1[CH:12]=[N:13][CH:14]=[CH:15][C:16]=1I)[CH:8]([CH3:10])[CH3:9])([CH3:4])([CH3:3])[CH3:2].[Cl:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1B(O)O>CCCCCCC.CCOC(C)=O>[C:1]([O:5][C:6](=[O:18])[N:7]([C:11]1[CH:12]=[N:13][CH:14]=[CH:15][C:16]=1[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=1[Cl:19])[CH:8]([CH3:10])[CH3:9])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 27343222-Chlorophenylboronic acidHCID 70663198HCID 70663198, compound

Product 1

HCID 70663414HCID 70663414, compound

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared in analogy to example 72, from (4-iodo-pyridin-3-yl)-isopropyl-carbamic acid tert-butyl ester and 2-chlorophenylboronic acid (CAS RN 1679-18-1) and using a gradient of n-heptane:EtOAc (100:0 to 50:50) for the chromatographic purification. Colorless oil (85%). MS (ESI): m/z=347.15 [M+H]+.

Workup

  1. customfor the chromatographic purification

Sources & evidence

ORD record
ord-389e4378359f4038a8666acd2695586e
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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