反应详情

To a solution of 3-cyano-5-trifluoromethyl-benzoic acid methyl ester (0.084 g, 0.367 mmol) in dioxane (0.5 mL) was added water (0.5 mL) and lithium hydroxide monohydrate (19.2 mg, 0.458 mmol) and the resulting mixture was stirred at room temperature for 1 h. The reaction mixture was evaporated, the residue was taken up in dioxane and 10% aqueous citric acid solution and the layers were separated. The aqueous layer was extracted twice with EtOAc and the organic layers were washed with brine, dried over MgSO4, filtered and evaporated. Light brown solid (0.09 g; 98%). MS (ESI): m/z=214.01 [M−H]−.

1. customThe reaction mixture was evaporated
2. custom10% aqueous citric acid solution and the layers were separated
3. extractionThe aqueous layer was extracted twice with EtOAc
4. washthe organic layers were washed with brine
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. customevaporated