2-Methylphenyl boronic acid → HCID 70663369, compound

HRID 878187Notes

Reaction equation

HRID 878187 reaction equation
I[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[NH:8][CH2:9][CH2:10][C:11]#[N:12].[CH3:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1B(O)O>CCCCCCC.CCOC(C)=O>[C:14]1([CH3:13])[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[NH:8][CH2:9][CH2:10][C:11]#[N:12]

Participants

4

Reactant 2

HCID 27332672-Methylphenyl boronic acidHCID 70663578HCID 70663578, compound

Product 1

HCID 70663369HCID 70663369, compound

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared in analogy to example 72, from 3-(4-iodo-pyridin-3-ylamino)-propionitrile and 2-methylphenylboronic acid (CAS RN 16419-60-6) and using a gradient of heptane:EtOAc (100:0 to 0:100) for the chromatographic purification. Light brown solid (81%). MS (ESI): m/z=238.13 [M+H]+.

Workup

  1. customfor the chromatographic purification

Sources & evidence

ORD record
ord-7b37e4da01234c69a60badee943fb918
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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