HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluorophenylboronic acid → [4-(2-Fluoro-phenyl)-pyridin-3-ylamino]-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluorophenylboronic acid | HCID 2734354 | — |
| Reactant | Ethylacetate heptane | HCID 21899848 | — |
| Reactant | N-[4-(4,5-Difluoro-2-methoxy-phenyl)-pyridin-3-yl]-N-(2-methanesulfonyl-ethyl)-2,6-bis-trifluoromethyl-isonicotinamide | HCID 86670771 | — |
| Product | [4-(2-Fluoro-phenyl)-pyridin-3-ylamino]-acetic acid methyl ester | HCID 70663196 | — |
Reaction Steps
The title compound was prepared in analogy to example 72, from (4-iodo-pyridin-3-ylamino)-acetic acid methyl ester (example 176, intermediate b) and 2-fluorophenylboronic acid (CAS RN 1193-03-9) and using a gradient of n-heptane:EtOAc (100:0 to 0:100) for the chromatographic purification. Off-white solid (37%). MS (ESI): m/z=261.104 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-5ad44ac94c374a79b0a42f978d5bc4fc |
| Source note | uspto-grants-2015_03 |