HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → (2-Chloro-4-iodo-pyridin-3-yl)-methyl-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | (2-Chloro-4-iodo-pyridin-3-yl)-carbamic acid tert-butyl ester | HCID 24229170 | — |
| Reactant | N-[4-(2-Chloro-phenyl)-pyridin-3-yl]-N-(2-methanesulfonyl-ethyl)-3,5-bis-trifluoromethyl-benzamide | HCID 86670734 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | (2-Chloro-4-iodo-pyridin-3-yl)-methyl-carbamic acid tert-butyl ester | HCID 86670802 | — |
Reaction Steps
The title compound was prepared in analogy to example 85, intermediate c, from (2-chloro-4-iodo-pyridin-3-yl)-carbamic acid tert-butyl ester (CAS RN 855784-39-3) and methyl iodide and using a gradient of n-heptane:EtOAc (100:0 to 50:50) for the chromatographic purification. Colorless solid (88%). MS (ESI): m/z=368.99 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-a3f642eabe7a4cfdaf15a594f86d1a9a |
| Source note | uspto-grants-2015_03 |