1-Chloro-2-methanesulfonylethane → HCID 70663268, compound

HRID 878358Notes

Reaction equation

HRID 878358 reaction equation
FC1C(F)=CC(C2C=CN=CC=2N([CH2:32][CH2:33][S:34]([CH3:37])(=[O:36])=[O:35])C(=O)C2C=C(C(F)(F)F)N=C(C(F)(F)F)C=2)=C(OC)C=1.[C:40]([O:44][C:45](=[O:64])[NH:46][C:47]1[CH:48]=[N:49][CH:50]=[CH:51][C:52]=1[C:53]1[CH:58]=[CH:57][CH:56]=[CH:55][C:54]=1[O:59][C:60]([F:63])([F:62])[F:61])([CH3:43])([CH3:42])[CH3:41].ClCCS(C)(=O)=O>CCCCCC.CCOC(C)=O>[C:40]([O:44][C:45](=[O:64])[N:46]([CH2:32][CH2:33][S:34]([CH3:37])(=[O:36])=[O:35])[C:47]1[CH:48]=[N:49][CH:50]=[CH:51][C:52]=1[C:53]1[CH:58]=[CH:57][CH:56]=[CH:55][C:54]=1[O:59][C:60]([F:61])([F:62])[F:63])([CH3:43])([CH3:41])[CH3:42]

Participants

5

Reactant 3

HCID 3035331-Chloro-2-methanesulfonylethaneHCID 70663425HCID 70663425, compoundHCID 86670771N-[4-(4,5-Difluoro-2-methoxy-phenyl)-pyridin-3-yl]-N-(2-methanesulfonyl-ethyl)-2,6-bis-trifluoromethyl-isonicotinamide

Product 1

HCID 70663268HCID 70663268, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

The title compound was prepared in analogy to example 298, intermediate b, from [4-(2-trifluoromethoxy-phenyl)-pyridin-3-yl]-carbamic acid tert-butyl ester and 1-chloro-2-(methylsulfonyl)ethane and using a gradient of n-hexane:EtOAc (50:50 to 40:60) for the chromatographic purification. Colourless sticky solid (96%). MS (ESI): m/z=461.4 [M+H]+.

Workup

  1. customfor the chromatographic purification

Sources & evidence

ORD record
ord-fb692a3c3a9c493195bdb37081d717b5
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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