HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-2-methanesulfonylethane → HCID 70663268, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-2-methanesulfonylethane | HCID 303533 | — |
| Reactant | HCID 70663425 | HCID 70663425 | — |
| Reactant | N-[4-(4,5-Difluoro-2-methoxy-phenyl)-pyridin-3-yl]-N-(2-methanesulfonyl-ethyl)-2,6-bis-trifluoromethyl-isonicotinamide | HCID 86670771 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | HCID 70663268 | HCID 70663268 | — |
Reaction Steps
The title compound was prepared in analogy to example 298, intermediate b, from [4-(2-trifluoromethoxy-phenyl)-pyridin-3-yl]-carbamic acid tert-butyl ester and 1-chloro-2-(methylsulfonyl)ethane and using a gradient of n-hexane:EtOAc (50:50 to 40:60) for the chromatographic purification. Colourless sticky solid (96%). MS (ESI): m/z=461.4 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-fb692a3c3a9c493195bdb37081d717b5 |
| Source note | uspto-grants-2015_03 |