Trifluoroacetic anhydride → HCID 66682449, compound

HRID 878395Notes

Reaction equation

HRID 878395 reaction equation
[CH2:1]([O:8][CH2:9][C:10]1[CH2:14][C:13]([C:16]([Cl:19])([Cl:18])[Cl:17])(O)[N:12]([C:20]2[C:25]([Cl:26])=[CH:24][CH:23]=[CH:22][N:21]=2)[N:11]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(OC(=O)C(F)(F)F)=O>C(OC)C(C)C>[CH2:1]([O:8][CH2:9][C:10]1[CH:14]=[C:13]([C:16]([Cl:18])([Cl:19])[Cl:17])[N:12]([C:20]2[C:25]([Cl:26])=[CH:24][CH:23]=[CH:22][N:21]=2)[N:11]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 9845Trifluoroacetic anhydrideHCID 51050602HCID 51050602, compound

Product 1

HCID 66682449HCID 66682449, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 12250Ether, isobutyl methylSolvent

Conditions

Temperature
25 °C

Procedure

4.35 g of 3-[(benzyloxy)methyl]-1-(3-chloropyridin-2-yl)-5-(trichloromethyl)-4,5-dihydro-1H-pyrazol-5-ol were dissolved in 30 ml of methyl isobutyl ether. Then 3 g of trifluoroacetic anhydride were added (exothermic reaction). The mixture was stirred at 25° C. for a further 2 h, in the course of which the precipitate was formed. The precipitate was filtered off and washed. The yield was 95%.

Workup

  1. custom(exothermic reaction)
  2. customwas formed
  3. filtrationThe precipitate was filtered off
  4. washwashed

Sources & evidence

ORD record
ord-2f0cf2c13b174fd4846415d70c6b14d6
Source dataset
uspto-grants-2015_03
Patent number
US08987460B2

Reaction notes

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