Ammonia → 2-chloro-N-(4-chlorophenyl)oxazole-4-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	Ammonia	HCID 222	—
Reactant	4-Chloroaniline	HCID 7812	—
Reactant	Ethyl 2-chlorooxazole-4-carboxylate	HCID 2763184	—
Product	2-chloro-N-(4-chlorophenyl)oxazole-4-carboxamide	HCID 68804152	—

Reaction Steps

Prepared from ethyl 2-chlorooxazole-4-carboxylate (83.5 mg, 0.475 mmol) and 4-chloroaniline (60.5 mg, 0.475 mmol) as described in Example 154A: 1H NMR (500 MHz, DMSO-D6) δ ppm 7.37-7.45 (m, 2H), 7.81-7.89 (m, 2H), 8.91 (s, 1H), 10.45 (s, 1H). MS (DCI/NH3) m/z=274 (M+NH4)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08987453B2
Source dataset	uspto-grants-2015_03
ORD ID	ord-c136bda2f4af4ebd9ea446863b8ac294
Source note	uspto-grants-2015_03