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HRID878548

反应详情

EQUATION

反应方程式

HRID 878548 的结构方程式

REACTANTS

反应物

1
结构：CC(=O)c1ccc(N(C)C)cc1
HCID75037

4-Dimethylaminoacetophenone

C10H13NO

PRODUCTS

生成物

1
结构：CN(C)/C=C/C(=O)c1ccc(N(C)C)cc1
HCID71285027

未命名化合物

收率 35.8%

AUXILIARIES

试剂、催化剂与溶剂

3
结构：CC(=O)O
催化剂HCID176

Acetic Acid

C2H4O2

结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

结构：COC(OC)N(C)C
溶剂HCID78373

Methanamine, 1,1-dimethoxy-N,N-dimethyl-

C5H13NO2

PROCEDURE

实验过程

A solution of 1-[4-(dimethylamino)phenyl]ethanone (500 mg, 3.1 mmol) in DMF-DMA (10 mL), toluene (10 mL), and AcOH (2 drops), was heated under reflux conditions for 48 h. The solution was concentrated and purified by flash column chromatography (hexanes:EtOAc=8:2˜1:1) to give the title compound (121 mg, 18%) as a yellow solid.

WORKUP

后处理

  1. concentrationThe solution was concentrated
  2. custompurified by flash column chromatography (hexanes:EtOAc=8:2˜1:1)