Acetonitrile--water (1/1) → HCID 86725573, compound

HRID 878607Notes

Reaction equation

HRID 878607 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:10][O:11][C:12]2[N:16]([C:17]3[CH:22]=[C:21]([C:23]([OH:25])=[O:24])[CH:20]=[CH:19][N:18]=3)[N:15]=[CH:14][CH:13]=2)[CH:5]=[CH:6][C:7]=1[CH2:8][CH3:9].[C:26](#N)C.O>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:10][O:11][C:12]2[N:16]([C:17]3[CH:22]=[C:21]([C:23]([O:25][CH3:26])=[O:24])[CH:20]=[CH:19][N:18]=3)[N:15]=[CH:14][CH:13]=2)[CH:5]=[CH:6][C:7]=1[CH2:8][CH3:9]

Participants

3

Reactant 2

HCID 18373917Acetonitrile--water (1/1)HCID 86725574HCID 86725574, compound

Product 1

HCID 86725573HCID 86725573, compound

Procedure

The title compound was prepared from 2-[5-[(3-chloro-4-ethylphenyl)methoxy]pyrazol-1-yl]pyridine-4-carboxylic acid (EXAMPLE 95) according to the procedure for the preparation of Example 62. 1H NMR (400 MHz, CDCl3): δ 1.23 (3H, t, J=7.6 Hz), 2.76 (2H, q, J=7.6 Hz), 3.97 (3H, s), 5.18 (2H, s), 5.75 (1H, s), 7.26 (2H, s), 7.45 (1H, s), 7.58 (1H,$), 7.78 (1H, d, J=8.0 Hz), 8.33 (1H, s), 8.72 (1H, d, J=0.8 Hz). LCMS (mobile phase: 20%-95% Acetonitrile-Water-0.02% NH4OH): purity is >95%, Rt=4.602 min.

Workup

  1. customaccording to the procedure for the preparation of Example 62

Sources & evidence

ORD record
ord-b24515f5de524c328c8a1897c9a0f28c
Source dataset
uspto-grants-2015_03
Patent number
US08987461B2

Reaction notes

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