2-Bromopropane → HCID 69315203, compound

HRID 878633Notes

Reaction equation

HRID 878633 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:9][OH:10])=[C:6]([OH:8])[CH:7]=1.[CH:11](Br)([CH3:13])[CH3:12]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:9][OH:10])=[C:6]([O:8][CH:11]([CH3:13])[CH3:12])[CH:7]=1

Participants

3

Reactant 2

HCID 63582-BromopropaneHCID 3271485-Chloro-2-(hydroxymethyl)phenol

Product 1

HCID 69315203HCID 69315203, compound

Procedure

The title compound was prepared from 5-chloro-2-(hydroxymethyl)phenol (PREPARATION 7) and isopropylbromide according to the procedure for the preparation of Example 111, part A. 1H NMR (400 MHz, CDCl3): δ 1.36 (6H, d, J=6.4 Hz), 2.40 (1H, s), 4.55-4.59 (1H, m), 4.61 (2H, s), 6.86 (1H, d, J=2.0 Hz), 6.89 (1H, dd, J=1.6 Hz, 7.6 Hz), 7.18 (1H, d, J=7.6 Hz).

Sources & evidence

ORD record
ord-b88616baf9304d32a8038653a32f465d
Source dataset
uspto-grants-2015_03
Patent number
US08987461B2

Reaction notes

Loading…