Cyclopropylboronic acid → HCID 86725654, compound

HRID 878705Notes

Reaction equation

HRID 878705 reaction equation
Br[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([F:12])[CH:3]=1.[CH:13]1(B(O)O)[CH2:15][CH2:14]1>>[CH:13]1([C:2]2[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([F:12])[CH:3]=2)[CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 2760897Cyclopropylboronic acidHCID 113453114-Bromo-2-fluoro-benzoic acid methyl ester

Product 1

HCID 86725654HCID 86725654, compound

Procedure

The title compound was prepared from methyl 4-bromo-2-fluorobenzoate and cyclopropylboronic acid according to the procedure for the preparation of EXAMPLE 152, part A. 1H NMR (400 MHz, CDCl3): δ 0.74-0.78 (2H, m), 1.04-1.09 (2H, m), 1.87-1.94 (1H, m), 3.90 (3H, s), 6.75-6.79 (1H, m), 6.86-6.89 (1H, m), 7.79-7.82 (1H, m).

Sources & evidence

ORD record
ord-4bc0bad287bc42118ae937ab9d0dcdce
Source dataset
uspto-grants-2015_03
Patent number
US08987461B2

Reaction notes

Loading…