Cyclopropylboronic acid → HCID 86725657, compound

HRID 878707Notes

Reaction equation

HRID 878707 reaction equation
Br[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[Cl:12].[CH:13]1(B(O)O)[CH2:15][CH2:14]1>>[Cl:12][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:2]=1[CH:13]1[CH2:15][CH2:14]1)[C:6]([O:8][CH3:9])=[O:7]

Participants

3

Reactant 2

HCID 2760897Cyclopropylboronic acidHCID 22366763Methyl 4-bromo-3-chlorobenzoate

Product 1

HCID 86725657HCID 86725657, compound

Procedure

The title compound was prepared from methyl 4-bromo-3-chlorobenzoate and cyclopropylboronic acid according to the procedure for the preparation of EXAMPLE 152, part A. 1H NMR (400 MHz, CDCl3): δ 0.73-0.77 (2H, m), 1.07-1.12 (2H, m), 2.24-2.30 (1H, m), 3.90 (3H, s), 6.93 (1H, d, J=8.0 Hz), 7.80 (1H, dd, J=1.6 Hz, 8.0 Hz), 8.01 (1H, d, J=1.6 Hz).

Sources & evidence

ORD record
ord-5b04cc82b7cc41db93903506bafd5656
Source dataset
uspto-grants-2015_03
Patent number
US08987461B2

Reaction notes

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