HCID 84658805, compound → HCID 86725658, compound

HRID 878708Notes

Reaction equation

HRID 878708 reaction equation
[OH:1][C:2]1[N:6]([C:7]2[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][N:8]=2)[N:5]=[CH:4][CH:3]=1.[Cl:15][C:16]1[CH:17]=[C:18]([CH2:25]O)[CH:19]=[CH:20][C:21]=1[CH:22]1[CH2:24][CH2:23]1>>[Cl:15][C:16]1[CH:17]=[C:18]([CH2:25][O:1][C:2]2[N:6]([C:7]3[CH:12]=[C:11]([C:13]#[N:14])[CH:10]=[CH:9][N:8]=3)[N:5]=[CH:4][CH:3]=2)[CH:19]=[CH:20][C:21]=1[CH:22]1[CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 84658805HCID 84658805, compoundHCID 178510213HCID 178510213, compound

Product 1

HCID 86725658HCID 86725658, compound

Procedure

The title compound was prepared from 2-(5-hydroxy-1H-pyrazol-1-yl)pyridine-4-carbonitrile and (3-chloro-4-cyclopropylphenyl)methanol according to the procedure for the preparation of Example 39, part C. 1H NMR (400 MHz, CDCl3): δ 0.68-0.71 (2H, m), 1.01-1.06 (2H, m), 2.16-2.23 (1H, m), 5.17 (2H, s), 5.73 (1H, d, J=2.0 Hz), 6.94 (1H, d, J=8.0 Hz), 7.20 (1H, dd, J=1.6 Hz, 8.0 Hz), 7.40 (1H, dd, J=1.2 Hz, 5.2 Hz), 7.45 (1H, d, J=1.6 Hz), 7.56 (1H, d, J=1.6 Hz), 8.03 (1H, s), 8.71 (1H, d, J=4.8 Hz). [M+H] Calc'd for C19H15ClN4O, 351; Found, 351.

Sources & evidence

ORD record
ord-1ffc10556dda4535aa59deac19123c9b
Source dataset
uspto-grants-2015_03
Patent number
US08987461B2

Reaction notes

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