2,2-Dimethyl-1,3-dioxane-4,6-dione → Ethyl 4-(2-chlorophenyl)-3-oxobutanoate

HRID 878725Notes

Reaction equation

HRID 878725 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=O.[CH3:12][C:13]1(C)[O:18]C(=O)[CH2:16][C:15](=O)[O:14]1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9](=[O:11])[CH2:12][C:13]([O:14][CH2:15][CH3:16])=[O:18]

Participants

3

Reactant 2

HCID 162492,2-Dimethyl-1,3-dioxane-4,6-dioneHCID 17124o-Chlorophenylacetic acid

Product 1

HCID 13069496Ethyl 4-(2-chlorophenyl)-3-oxobutanoateYield 43%

Procedure

The title compound was prepared in 43% yield from 2-(2-chlorophenyl)acetic acid and 2,2-dimethyl-1,3-dioxane-4,6-dione according to the procedure for the preparation of Example 162, part A.

Sources & evidence

ORD record
ord-368e12014ec64638ba0e77028400cb49
Source dataset
uspto-grants-2015_03
Patent number
US08987461B2

Reaction notes

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