2,4-Difluorophenylacetic acid → HCID 26597804, compound

HRID 878741Notes

Reaction equation

HRID 878741 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][C:10]([OH:12])=O.[K+].[CH3:14][O:15][C:16](=[O:21])[CH2:17]C([O-])=O>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][C:10](=[O:12])[CH2:17][C:16]([O:15][CH3:14])=[O:21]

Participants

3

Reactant 2

HCID 1235812,4-Difluorophenylacetic acidHCID 2724687Potassium methyl malonate

Product 1

HCID 26597804HCID 26597804, compound

Procedure

The title compound was prepared from 2-(2,4-difluorophenyl)acetic acid and 3-methoxy-3-oxopropanoic acid potassium salt according to the procedure for the preparation of Example 170, part A. 1H NMR (300 MHz, CDCl3): δ 3.54 (2H, s), 3.76 (3H, s), 3.86 (2H, s), 6.83-6.90 (2H, m), 7.13-7.19 (1H, m).

Sources & evidence

ORD record
ord-866ba83166284c7d98bb420ec6090898
Source dataset
uspto-grants-2015_03
Patent number
US08987461B2

Reaction notes

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