反应详情

温度

150 °C

A mixture of rpm282 (0.260 g, 0.841 mmol) methyl-2-aminobenzoate (0.139 g, 0.925 mmol, 1.2 eq) and methansulfonic acid (0.088 g, 0.925 mmol, 1.1 eq) in ethanol (5 mL) was heated in the microwave at 150° C. for 5 min. The reaction mixture was cooled to 0° C., and the orange precipitate was collected by filtration and dried, to give pure rpm335 (0.207 g, 0.498 mmol, 59%). MS (API-ES): m/z 416 (M+H)+; HRMS (API-ES) m/z Found: 416.1276 (M+H)+.

1. temperatureThe reaction mixture was cooled to 0° C.
2. filtrationthe orange precipitate was collected by filtration
3. customdried
4. customto give pure rpm335 (0.207 g, 0.498 mmol, 59%)