1-(Chloromethyl)-2,4-difluorobenzene → 2-(1-benzyl-1H-indole-6-yl)acetic acid

HRID 878955Notes

Reaction equation

HRID 878955 reaction equation
[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1[CH2:4]Cl.[CH2:11]([N:18]1[C:26]2[C:21](=[CH:22][CH:23]=[C:24]([CH2:27][C:28]([OH:30])=[O:29])[CH:25]=2)[CH:20]=[CH:19]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1[CH2:4][N:18]1[C:26]2[C:21](=[CH:22][CH:23]=[C:24]([CH2:27][C:28]([OH:30])=[O:29])[CH:25]=2)[CH:20]=[CH:19]1.[CH2:11]([N:18]1[C:26]2[C:21](=[CH:22][CH:23]=[C:24]([CH2:27][C:28]([OH:30])=[O:29])[CH:25]=2)[CH:20]=[CH:19]1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 27369481-(Chloromethyl)-2,4-difluorobenzeneHCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acid

Product 2

HCID 544889242-(1-benzyl-1H-indole-6-yl)acetic acidHCID 681844182-[1-(2,4-difluorobenzyl)-1H-indole-6-yl]acetic acid

Procedure

The titled compound (35 mg) as a white solid was prepared from the compound [4-6] obtained in the process (6) of Example 4 (100 mg) and 2,4-difluorobenzyl chloride according to the method of the process (7) of Example 4.

Sources & evidence

ORD record
ord-82860b74122344fba895bbcdbb5aa10a
Source dataset
uspto-grants-2015_03
Patent number
US08987473B2

Reaction notes

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