N-Methyl-D-glucamine → HCID 131732628, compound

HRID 879021Notes

Reaction equation

HRID 879021 reaction equation
[CH:1]1[CH:6]=[CH:5][C:4]([CH2:7][O:8][CH2:9][C@@H:10]([N:14]([CH2:33][C:34]([OH:36])=[O:35])[CH2:15][CH2:16][N:17]([CH2:29][C:30]([OH:32])=[O:31])[CH2:18][CH2:19][N:20]([CH2:25][C:26]([OH:28])=[O:27])[CH2:21][C:22]([OH:24])=[O:23])[C:11]([OH:13])=[O:12])=[CH:3][CH:2]=1.[NH:37]([CH2:39][C@@H:40]([C@H:42]([C@@H:44]([C@@H:46]([CH2:48][OH:49])[OH:47])[OH:45])[OH:43])[OH:41])[CH3:38]>O>[CH:1]1[CH:6]=[CH:5][C:4]([CH2:7][O:8][CH2:9][C@@H:10]([N:14]([CH2:33][C:34]([OH:36])=[O:35])[CH2:15][CH2:16][N:17]([CH2:29][C:30]([OH:32])=[O:31])[CH2:18][CH2:19][N:20]([CH2:21][C:22]([OH:24])=[O:23])[CH2:25][C:26]([OH:28])=[O:27])[C:11]([OH:13])=[O:12])=[CH:3][CH:2]=1.[NH:37]([CH2:39][C@@H:40]([C@H:42]([C@@H:44]([C@@H:46]([CH2:48][OH:49])[OH:47])[OH:45])[OH:43])[OH:41])[CH3:38]

Participants

4

Reactant 2

HCID 8567N-Methyl-D-glucamineHCID 76958772HCID 76958772, compound

Product 1

HCID 131732628HCID 131732628, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In a representative procedure and according to a preferred embodiment, the BOPTA ligand is solved in water for injection (WFI) containing about 2 equivalents of meglumine, at room temperature, forming a BOPTA-meglumine salt 1:2 solution, with a concentration of about 0.1-0.15 M. Such solution is then eluted through a column containing the Amberlite IRC 748i resin, saturated with Gd(III) ions, at an elution rate of about 1 to 1.5 bed-volume/h. even more preferably, the present process comprises the steps of:

Sources & evidence

ORD record
ord-f92c1b43185949d18f2f517ac9bc05c0
Source dataset
uspto-grants-2015_03
Patent number
US08987508B2

Reaction notes

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