4-Chlorobenzoyl chloride → tert-Butyl (4-Chlorobenzoyl)oxycarbamate

HRID 879024Notes

Reaction equation

HRID 879024 reaction equation
[OH:1][NH:2][C:3](=[O:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6].[Cl:10][C:11]1[CH:19]=[CH:18][C:14]([C:15](Cl)=[O:16])=[CH:13][CH:12]=1>C(Cl)Cl>[Cl:10][C:11]1[CH:19]=[CH:18][C:14]([C:15]([O:1][NH:2][C:3](=[O:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6])=[O:16])=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 85014-Chlorobenzoyl chlorideHCID 97534tert-butyl N-hydroxycarbamate

Product 1

HCID 23655003tert-Butyl (4-Chlorobenzoyl)oxycarbamate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl hydroxycarbamate (9.76 g, 73.3 mmol) in DCM (120 mL) at 0° C., is added 4-chlorobenzoyl chloride (8.13 mL, 73.3 mmol) followed by the dropwise addition of

Workup

  1. additionfollowed by the dropwise addition of

Sources & evidence

ORD record
ord-7c4cff7d7ff94ee292992348b3cbb040
Source dataset
uspto-grants-2015_03
Patent number
US08987504B2

Reaction notes

Loading…