Trifluoroacetic acid → (5S,8S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,8-diisopropyl-12-methoxy-4,10-dimethyl-3,6,9-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid

Participants

Reaction Steps

650 mg (0.94 mmol) N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valyl-N-[(3R,4S,5S)-1-tert.-butoxy-3-methoxy-5-methyl-1-oxoheptane-4-yl]-N-methyl-L-valinamide (intermediate 3) were absorbed by 5 ml dichlormethane, 5 ml trifluoroacetic acid were added and then stirred overnight at RT. Then, the mixture was evaporated in vacuum and the remaining residue was purified using HPLC. 430 mg (72% o. th.) of the title compound were obtained as a colorless foam.

Provenance & Evidence