HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (1S)-1-Benzyl-2-(benzyloxy)ethylamine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert.-Butyl-[(2S)-1-(benzyloxy)-3-phenylpropan-2-yl]carbamate | HCID 66837219 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (1S)-1-Benzyl-2-(benzyloxy)ethylamine hydrochloride | HCID 12815229 | — |
Reaction Steps
220 mg (644 μmol) of -tert.-butyl-[(2S)-1-(benzyloxy)-3-phenylpropane-2-yl]carbamate (intermediate 30) were dissolved in 11 ml of a 4 N hydrogen chloride solution diluted in dioxane and stirred for 1 hour at RT. Then, the batch was evaporated and the residue vacuum dried. The yield was 138 mg (77% o. th.) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987209B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-cb062d12c8544f64bd10ff6f71d0864f |
| Source note | uspto-grants-2015_03 |