反应详情

温度

40 °C

To a solution of (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(5′-methoxy-2,3′-bipyridin-4-yl)-5-methylbenzo[d]thiazol-6-yl)ethyl pivalate (40.5 mg, 0.063 mmol) in THF (0.5 mL) and methanol (0.5 mL) was added NaOH (0.5 mL, 2N solution). The reaction mixture was heated at 40° C. for 4 h, cooled, diluted with satd. aqueous NH4Cl, and extracted with ethyl acetate. The organic layer was dried over Na2SO4, filtered and concentrated to give the crude product which was used without further purification. LCMS-ESI+: calc'd for C31H31ClN3O3S: 560.2 (M+H+); Found: 560.0 (M+H+).

1. temperaturecooled
2. additiondiluted with satd
3. extractionaqueous NH4Cl, and extracted with ethyl acetate
4. dry with materialThe organic layer was dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated