反应详情

(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(3-(1-methyl-1H-indazol-5-yl)-2-oxoimidazolidin-1-yl)benzo[d]thiazol-6-yl)acetic acid (1.3 mg) was prepared in a similar manner as compound (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(3-(1-methyl-1H-indazol-5-yl)-2-oxotetrahydropyrimidin-1(2H)-yl)benzo[d]thiazol-6-yl)acetic acid except using imidazolidin-2-one instead of tetrahydropyrimidin-2(1H)-one. LCMS-ESI+: calc'd for C31H30ClN5O4S: 604.2 (M+H+); Found: 604.2 (M+H+); 1H-NMR 400 MHz, (CD3OD) δ 7.99 (s, 1H), 7.82 (m, 1H), 7.66 (m, 1H), 7.60-7.48 (m, 5H), 7.42 (m, 1H), 5.21 (s, 1H), 4.33 (m, 1H), 4.22 (m, 2H), 4.06 (s, 3H), 3.64 (m, 1H), 2.55 (s, 3H), 0.96 (s, 9H).