反应详情

温度

60 °C

To a solution of (S)-ethyl 2-(2-(2-(1H-indazol-5-yl)pyridin-4-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetate (110 mg, 0.18 mmol) in DMF (3 mL) was added Cs2CO3 (117 mg, 0.36 mmol) and 1-Boc-3-iodoazetidine (76 mg, 0.27 mmol). The reaction mixture was heated at 60° C. overnight. The reaction mixture was washed by saturated NaHCO3, extracted by EtOAc, the organic phase was dried over MgSO4, filtered, concentrated down, purified by silica gel column, eluting by 0-60% EtOAc in hexanes to give the product. LCMS-ESI+: calc'd for C42H44ClN5O5S: 766.3 (M+H+); found: 766.3.

1. washThe reaction mixture was washed by saturated NaHCO3
2. extractionextracted by EtOAc
3. dry with materialthe organic phase was dried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated down
6. custompurified by silica gel column
7. washeluting by 0-60% EtOAc in hexanes
8. customto give the product