Trifluoroacetic acid → HCID 86700290, compound

HRID 879475Notes

Reaction equation

HRID 879475 reaction equation
[CH3:1][N:2]1[C:10]2[CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][C:5]=2[C:4]([CH3:18])=[N:3]1.[C:19]([OH:25])([C:21]([F:24])([F:23])[F:22])=[O:20]>C(Cl)Cl>[F:22][C:21]([F:24])([F:23])[C:19]([OH:25])=[O:20].[CH3:1][N:2]1[C:10]2[CH2:9][CH2:8][NH:7][CH2:6][C:5]=2[C:4]([CH3:18])=[N:3]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86729507HCID 86729507, compound

Product 1

HCID 86700290HCID 86700290, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
23 °C

Procedure

A solution of tert-butyl 1,3-dimethyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate (all of the product from the previous reaction above) in DCM (2.0 mL) was treated with TFA (500 μL), then stirred for 3 h at 23° C. The reaction was then concentrated, giving the desired product in crude form. The material was immediately used in the next reaction. LCMS-ESI+: calc'd for C8H13N3: 152.1 (M+H+); Found: 152.0 (M+H+).

Workup

  1. concentrationThe reaction was then concentrated

Sources & evidence

ORD record
ord-98c913408461437fbc465b897dcba8cc
Source dataset
uspto-grants-2015_03
Patent number
US08987250B2

Reaction notes

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