Potassium Carbonate → HCID 86700293, compound

HRID 879478Notes

Reaction equation

Br[C:2]1[S:3][C:4]2[C:10]([C:11]3[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=3)=[C:9]([C@H:18]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])[C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:8]([CH3:29])=[CH:7][C:5]=2[N:6]=1.[Cl:30][C:31]1[CH:36]=[C:35](B(O)O)[CH:34]=[C:33]([Cl:40])[N:32]=1.O1CCOCC1.C([O-])([O-])=O.[K+].[K+]>CCO.O.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[C:25]([O:24][C@@H:18]([C:9]1[C:8]([CH3:29])=[CH:7][C:5]2[N:6]=[C:2]([C:35]3[CH:34]=[C:33]([Cl:40])[N:32]=[C:31]([Cl:30])[CH:36]=3)[S:3][C:4]=2[C:10]=1[C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1)[C:19]([O:21][CH2:22][CH3:23])=[O:20])([CH3:28])([CH3:27])[CH3:26]

Participants

Conditions

Temperature: 100 °C

Procedure

A microwave tube was charged with Pd(PPh3)4 (4 mg), (S)-ethyl 2-(2-bromo-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetate (25 mg), the 2,6-dichloropyridin-4-ylboronic acid (10 mg), dioxane (250 μL) and 2M aq K2CO3 (100 μL). The vessel was sealed and heated to 100° C. overnight. At 16 h, the reaction had only reached ˜60% conversion. The reaction was cooled to 23° C., diluted with absolute EtOH (1.5 mL) and H2O (500 μL), and was purified by reverse phase HPLC, eluting by 5-100% acetonitrile in H2O with 0.1% TFA to give the desired product. LCMS-ESI+: calc'd for C27H25Cl3N2O3S: 563.1, 565.1, 567.1 (M+H+); Found: 563.1, 565.0, 567.1 (M+H+).

Workup

customThe vessel was sealed
temperatureThe reaction was cooled to 23° C.
customwas purified by reverse phase HPLC
washeluting by 5-100% acetonitrile in H2O with 0.1% TFA

Sources & evidence

ORD record: ord-69c6459f15c74ee9bb4983d28c0d2cfa
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08987250B2

Reaction notes

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