Tetrahydrofuran → HCID 86700297, compound

HRID 879481Notes

Reaction equation

[C:1]([O:5][C@@H:6]([C:12]1[C:33]([CH3:34])=[CH:32][C:15]2[N:16]=[C:17]([C:19]3[CH:20]=[C:21]4[C:25](=[CH:26][CH:27]=3)[N:24]([CH3:28])[C:23](=[O:29])[C:22]4([CH3:31])[CH3:30])[S:18][C:14]=2[C:13]=1[C:35]1[CH:40]=[CH:39][C:38]([Cl:41])=[CH:37][CH:36]=1)[C:7]([O:9]CC)=[O:8])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].C1COCC1>CCO>[C:1]([O:5][C@@H:6]([C:12]1[C:33]([CH3:34])=[CH:32][C:15]2[N:16]=[C:17]([C:19]3[CH:20]=[C:21]4[C:25](=[CH:26][CH:27]=3)[N:24]([CH3:28])[C:23](=[O:29])[C:22]4([CH3:30])[CH3:31])[S:18][C:14]=2[C:13]=1[C:35]1[CH:36]=[CH:37][C:38]([Cl:41])=[CH:39][CH:40]=1)[C:7]([OH:9])=[O:8])([CH3:2])([CH3:3])[CH3:4]

Participants

Conditions

Temperature: 50 °C

Procedure

The crude (S)-ethyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(1,3,3-trimethyl-2-oxoindolin-5-yl)benzo[d]thiazol-6-yl)acetate from the reaction above was treated with 1.0 M aq NaOH (2 mL), THF (4 mL), and absolute EtOH (2 mL). The reaction was heated to 50° C. for 19 h. The reaction was cooled to 23° C., and filtered (0.45 micron teflon syringe filter). The filtrate was purified by reverse phase HPLC, eluting by 5-100% acetonitrile in H2O with 0.1% TFA to give the desired product. LCMS-ESI+: calc'd for C31H31ClN2O4S: 563.2, 565.2 (M+H+); Found: 563.3, 565.3 (M+H+). +). 1H NMR (400 MHz, CD3OD): δ 8.05-7.94 (m, 2H), 7.81 (s, 1H), 7.73-7.64 (m, 1H), 7.64-7.54 (m, 3H), 7.14 (d, J=8.2 Hz, 1H), 5.26 (s, 1H), 3.27 (s, 3H), 2.61 (s, 3H), 1.41 (s, 6H), 0.98 (s, 9H).

Workup

temperatureThe reaction was cooled to 23° C.
filtrationfiltered
filtration(0.45 micron teflon syringe filter)
customThe filtrate was purified by reverse phase HPLC
washeluting by 5-100% acetonitrile in H2O with 0.1% TFA

Sources & evidence

ORD record: ord-aefc4e8d28774889a65677e519dfec8c
Source dataset: uspto-grants-2015_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08987250B2

Reaction notes

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