Hydrochloric Acid → (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(3-(piperazin-1-yl)phenyl)benzo[d]thiazol-6-yl)acetic acid

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Reaction Steps

To a solution of (S)-2-tert-butoxy-2-(2-(3-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenyl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)acetic acid (from above) in 1,4-dioxane (5 mL) was added 4M HCl in 1,4-dioxane (1 mL, 4 mmol). The reaction was stirred at rt for 6 h. A saturated solution of NaHCO3 (10 mL) was added carefully. The layers were separated, and the organic layer was dried, filtered, and concentrated in vacuo and used without further purification. LCMS-ESI+: calc'd for C30H33ClN3O3S: 550.2 (M+H+); Found: 550.2 (M+H+).

Provenance & Evidence