反应详情

To a solution of (S)-2-tert-butoxy-2-(2-(3-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenyl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)acetic acid (from above) in 1,4-dioxane (5 mL) was added 4M HCl in 1,4-dioxane (1 mL, 4 mmol). The reaction was stirred at rt for 6 h. A saturated solution of NaHCO3 (10 mL) was added carefully. The layers were separated, and the organic layer was dried, filtered, and concentrated in vacuo and used without further purification. LCMS-ESI+: calc'd for C30H33ClN3O3S: 550.2 (M+H+); Found: 550.2 (M+H+).

1. customThe layers were separated
2. customthe organic layer was dried
3. filtrationfiltered
4. concentrationconcentrated in vacuo
5. customused without further purification