Oxalyl chloride → 2-Methyl-1,3-oxazole-4-carbonyl chloride

HRID 879890Notes

Reaction equation

HRID 879890 reaction equation
[CH3:1][C:2]1[O:3][CH:4]=[C:5]([C:7]([OH:9])=O)[N:6]=1.C(Cl)(=O)C([Cl:13])=O>C(Cl)Cl>[CH3:1][C:2]1[O:3][CH:4]=[C:5]([C:7]([Cl:13])=[O:9])[N:6]=1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 5394042-Methyloxazole-4-carboxylic acid

Product 1

HCID 146590622-Methyl-1,3-oxazole-4-carbonyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirring solution of 2-methyl-oxazole-4-carboxylic acid (30 mg) in DCM (2.0 mL), oxalyl chloride (3.0 eq) was added at room temperature. The reaction mixture was stirred for 30 minutes. Solvents were evaporated and dried under vacuo to afford 2-methyl-oxazole-4-carbonyl chloride.

Workup

  1. customSolvents were evaporated
  2. customdried under vacuo

Sources & evidence

ORD record
ord-ba12ec60d762485fb78366f70c7b32b0
Source dataset
uspto-grants-2015_03
Patent number
US08987295B2

Reaction notes

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