反应详情

3-Methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid (Intermediate 6) (0.44 g, 2.4 mmol) was stirred in thionyl chloride (2.00 mL, 27.4 mmol) at reflux for 2 h. The cooled mixture was concentrated and dried under vacuum. Intermediate 12A was used directly for the next step without further purification.

1. temperatureat reflux for 2 h
2. concentrationThe cooled mixture was concentrated
3. customdried under vacuum
4. customIntermediate 12A was used directly for the next step without further purification