HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3-Methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-Methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid | HCID 22937754 | — |
| Product | 3-Methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carbonyl chloride | HCID 86730082 | — |
Reaction Steps
3-Methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid (Intermediate 6) (0.44 g, 2.4 mmol) was stirred in thionyl chloride (2.00 mL, 27.4 mmol) at reflux for 2 h. The cooled mixture was concentrated and dried under vacuum. Intermediate 12A was used directly for the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08993557B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-dbb75d55af30415692c5a67e12d59162 |
| Source note | uspto-grants-2015_03 |